# AI Biologist - Protein Design & Engineering at LatchBio

- Company: LatchBio
- Status: Open
- Workplace: Remote
- Location: San Francisco (preferred) · Remote
- Level: Mid-level
- Discipline: AI & ML
- Employment: Full-time
- Salary: $140K–180K
- Posted: 2026-11-14
- Skills: AI, biology, protein design
- Apply: https://jobs.ashbyhq.com/LatchBio/d0a50576-fab7-488c-8250-f533a5c37bc6

## Description

Latch builds rigorous scientific benchmarks (benchmarks.bio http://benchmarks.bio) for AI agents across biology. We work with frontier labs and pharma to measure whether agents can handle real biological workflows: the messy, multi-layer reasoning that matters in the field.

 

We're seeking an AI Biologist to join our Protein Design & Engineering team, working at the frontier of what artificial intelligence can achieve in biology.

 


ABOUT THE ROLE

AI agents can now run the full protein design toolkit: generate backbones, design sequences, predict complexes, score interfaces and propose mutations. The open question is whether they make good decisions with it. We are building benchmarks that test exactly that, from designing a new binder from scratch to improving an existing one toward a measured function.

 

You will work across three connected areas:

 

 - De novo design. Given a target and a goal, can an agent design, filter and choose candidates that actually work? Tasks test the decisions that separate a real hit from a confident-looking failure: which design tool to trust, which filter to apply, which candidates to send to the lab.

 - Protein–protein interactions. Can an agent reason about a complex correctly? Tasks test whether it finds the true interface and its hotspots, tells a real interface from a crystal contact, reconciles co-folding models that disagree, and predicts how mutations change binding affinity and specificity.

 - Optimization. Given a de novo or redesigned protein, can an agent improve affinity, stability, expression or developability withou

More LatchBio roles: https://deviantjobs.com/companies/latchbio