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Flagship Pioneering, Inc.

Principal Data Engineer

Cambridge, MA USA

Python · Kubernetes · Genomics · Stem cell · Biology

What if you could join a rapidly growing company and play a critical role in bringing new medicines to patients by helping scale the programmable infrastructure behind a new human cellular biology platform?

About Vesalius

Vesalius Therapeutics is pioneering a new platform to generate breakthrough treatments for common diseases. Our platform combines large-scale human genetics, genomics, stem cell studies, high-dimensional cellular phenotyping, and artificial intelligence to uncover causal biology and identify optimal intervention points for new therapies. Vesalius was founded in 2019 by Flagship Pioneering.

Role Overview

We are seeking a Principal Data Engineer to lead the architecture and evolution of the data platform underpinning our human genetics, multi-omics, and high-content imaging programs.

This is a senior, hands-on leadership role with broad technical authority. As the architectural lead for data engineering, you will set the direction for our AWS environment and the pipelines, catalog, and access layers built on it, defining the technical roadmap and the standards others build against. The scope spans core cloud data engineering (orchestration, warehousing, infrastructure as code, cost governance) and the distinctive challenges of scientific data: connecting each microscopy image to its cell line, donor, and study of origin, and enabling scientists to answer genotype questions directly, without specialist intervention.

You will join a focused, high-impact team supporting a research organization whose data generation and analytical ambitions are expanding r

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